Cytochrome P450 Reductase Recombinant Rabbit Monoclonal Antibody [JB54-31] (ET7107-35)

UNIPROT #

P16435

PROTEIN NAME

Cytochrome P450 Reductase

SYNONYMS

CPR antibody;CYPOR antibody;Cytochrome p450 oxidoreductase antibody;DKFZp686G04235 antibody;FLJ26468 antibody;NADPH Cytochrome P450 Reductase antibody;NADPH dependent cytochrome P450 reductase antibody;NADPH--cytochrome P450 reductase antibody;NCPR_HUMAN antibody;P450 (cytochrome) oxidoreductase antibody;P450 Cytochrome Oxidoreductase antibody;P450R antibody;por antibody

SEQUENCE SIMILARITIES

Belongs to the NADPH--cytochrome P450 reductase family.; In the N-terminal section; belongs to the flavodoxin family.; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

SUBCELLULAR LOCATION

Endoplasmic reticulum.

FUNCTION

Cytochrome P450 reductase (EC 1.6.2.4; also known as NADPH:ferrihemoprotein oxidoreductase, NADPH:hemoprotein oxidoreductase, NADPH:P450 oxidoreductase, P450 reductase, POR, CPR, CYPOR) is a membrane-bound enzyme required for electron transfer from NADPH to cytochrome P450 and other heme proteins including heme oxygenase in the endoplasmic reticulum of the eukaryotic cell. Since all microsomal P450 enzymes require POR for catalysis, it is expected that disruption of POR would have devastating consequences. POR knockout mice are embryonic lethal, probably due to lack of electron transport to extrahepatic P450 enzymes since liver-specific knockout of POR yields phenotypically and reproductively normal mice that accumulate hepatic lipids and have remarkably diminished capacity of hepatic drug metabolism. The reduction of cytochrome P450 is not the only physiological function of POR. The final step of heme oxidation by mammalian heme oxygenase requires POR and O2. In yeast, POR affects the ferrireductase activity, probably transferring electrons to the flavocytochrome ferric reductase.