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Cytokeratin 19 Recombinant Rabbit Monoclonal Antibody [SA30-06] (ET1601-6)

Price: Regular price $385.00

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Catalog# ET1601-6

Rabbit Monoclonal to Cytokeratin 19

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

  • mIHC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Cytokeratin 19 Recombinant Rabbit Monoclonal Antibody [SA30-06] (ET1601-6)

Immunogen

Synthetic peptide within human cytokeratin 19 aa 348-400 / 400.

Host

Rabbit

Positive Control

MCF-7 cell lysates, AGS, human liver tissue, human breast carcinoma tissue, human breast tissue, mouse liver tissue, human kidney tissue, human placenta tissue, MCF-7, human stomach carcinoma tissue, human colon tissue, mouse pancreas.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SA30-06

RRID

AB_3069617

APPLICATION DILUTION

  • WB

  • 1:500-1:5,000

  • IF-Cell

  • 1:500

  • IF-Tissue

  • 1:500

  • IHC-P

  • 1:1,000

  • FC

  • 1:1,000

  • mIHC

  • 1:3,000-1:10,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 44 kDa

Isotype

IgG

TARGET

UNIPROT #

P08727

PROTEIN NAME

Cytokeratin 19

SYNONYMS

40 kDa keratin intermediate filament antibody;CK 19 antibody;CK-19 antibody;CK19 antibody;Cytokeratin 19 antibody;Cytokeratin-19 antibody;K19 antibody;K1C19_HUMAN antibody;K1CS antibody;Keratin 19 antibody;Keratin type I 40 kD antibody;Keratin type I 40kD antibody;Keratin type I cytoskeletal 19 antibody;Keratin, type I cytoskeletal 19 antibody;Keratin, type I, 40 kd antibody;Keratin-19 antibody;KRT19 antibody;MGC15366 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.

DEVELOPMENTAL STAGE

Present in hair follicles at all stages of development.

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin 19 is a type I keratin. Keratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically found in the periderm, the transiently superficial layer that envelops the developing epidermis.

CITATIONS

  • Tianfu Wen,Chuan Li;

    Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway

  • Abnormal expression of ERα in cholangiocytes of patients with primary biliary cholangitis mediated intrahepatic bile duct inflammation

  • Bioprinting of hydrogel beads to engineer pancreatic tumor-stroma microtissues for drug screening

  • Zhao, C., Matalonga, J., Lancman, J. J., Liu, L., Xiao, C., Kumar, S., Gates, K. P., He, J., Graves, A., Huisken, J., Azuma, M., Lu, Z., Chen, C., Ding, B. S., & Dong, P. D. S.

    Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling

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