Daxx Recombinant Rabbit Monoclonal Antibody [SC54-06] (ET1610-7)

UNIPROT #

Q9UER7

PROTEIN NAME

Daxx

SYNONYMS

BING 2 antibody;BING2 antibody;CENP-C binding protein antibody;DAP 6 antibody;DAP6 antibody;DAXX antibody;DAXX_HUMAN antibody;Death associated protein 6 antibody;Death domain associated protein 6 antibody;Death domain associated protein antibody;Death domain-associated protein 6 antibody;EAP 1 antibody;EAP1 antibody;ETS1 associated protein 1 antibody;ETS1-associated protein 1 antibody;Fas binding protein antibody;Fas death domain associated protein antibody;Fas death domain-associated protein antibody;hDaxx antibody;MGC126245 antibody;MGC126246 antibody

SEQUENCE SIMILARITIES

Belongs to the DAXX family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Sumoylated with SUMO1 on multiple lysine residues.; Phosphorylated by HIPK1 upon glucose deprivation.; Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation. Ubiquitinated by MDM2; inducing its degradation. Deubiquitinated by USP7; leading to stabilize it.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Chromosome.

FUNCTION

Activation of the cell surface receptor FAS by FAS ligand leads to the initiation of apoptosis, a process necessary for the regulation of the immune system and tissue homeostasis. FAS-mediated apoptosis appears to involve a number of divergent and overlapping pathways. Daxx appears to be a central component of a FAS-mediated apoptotic pathway involving the activation of Jun N-terminal kinase (JNK). Although Daxx itself does not contain a death domain, it specifically binds to the death domain of FAS. Overexpression of Daxx activates the JNK pathway and enhances FAS-mediated apoptosis. The Daxx apoptotic pathway acts cooperatively with but is distinct from the FAS-mediated pathway that involves interactions between the death domain-containing protein FADD and the cysteine protease FLICE. Unlike the FAS-FADD-FLICE pathway, the Daxx pathway is sensitive to the apoptotic inhibitor protein Bcl-2.