FKBP51 Recombinant Rabbit Monoclonal Antibody [JB95-39] (ET7107-64)

UNIPROT #

Q13451

PROTEIN NAME

FKBP51

SYNONYMS

51 kDa FK506 binding protein 5 antibody;51 kDa FK506 binding protein antibody;51 kDa FK506-binding protein antibody;51 kDa FKBP antibody;54 kDa progesterone receptor associated immunophilin antibody;54 kDa progesterone receptor-associated immunophilin antibody;AIG 6 antibody;AIG6 antibody;Androgen regulated protein 6 antibody;Androgen-regulated protein 6 antibody;FF1 antigen antibody;FK506 binding protein 5 antibody;FK506-binding protein 5 antibody;FKBP 5 antibody;FKBP 51 antibody;FKBP 54 antibody;FKBP-5 antibody;FKBP-51 antibody;FKBP5 antibody;FKBP5_HUMAN antibody;FKBP54 antibody;HSP90 binding immunophilin antibody;HSP90-binding immunophilin antibody;MGC111006 antibody;OTTHUMP00000016268 antibody;P54 antibody;Peptidyl prolyl cis trans isomerase antibody;Peptidyl-prolyl cis-trans isomerase FKBP5 antibody;Peptidylprolyl cis trans isomerase antibody;PPIase antibody;PPIase FKBP5 antibody;Ptg 10 antibody;Ptg10 antibody;Rotamase antibody;T cell FK506 binding protein antibody

TISSUE SPECIFICITY

Widely expressed, enriched in testis compared to other tissues.

POST-TRANSLATIONAL MODIFICATION

Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. Several related immunophilins, FKBP12, FKBP51 and FKBP52, are characterized as cytosolic FK506-binding proteins, and following ligand binding, they functionally inhibit the phosphatase activity of calcineurin. The ubiquitously expressed FKBP12 also associates with the cytoplasmic domain of the TGFβ-type I receptor, where it stabilizes the inactive conformation of the receptor and blocks the activation of the TGFβ pathway. FKBP51 and FKBP52 are two highly related proteins. FKBP51 is predominantly expressed in T cells and is induced by glucocorticoids. FKBP51 mediates the effects of FK506 and rapamycin by inhibiting intracellular calcineurin activity, and by blocking T-cell activation and proliferation. FKBP52, known also as FKBP-59 or heat shock protein 56, is expressed in a variety of tissues and can also associate with the heat shock protein (hsp90) in mature steroid receptor complexes (6,8).