FOXA1 Mouse Monoclonal Antibody [A2E8] (EM1902-34)

UNIPROT #

P55317

PROTEIN NAME

FOXA1

SYNONYMS

forkhead box A1 antibody;Forkhead box protein A1 antibody;FOX A1 antibody;FOXA1 antibody;FOXA1_HUMAN antibody;hepatocyte nuclear factor 3 alpha antibody;Hepatocyte nuclear factor 3-alpha antibody;HNF 3A antibody;HNF-3-alpha antibody;HNF-3A antibody;HNF3A antibody;MGC33105 antibody;TCF 3A antibody;TCF-3A antibody;TCF3A antibody;Transcription factor 3A antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin as a pioneer factor. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts as a pioneer factor for ERa in ERα+ breast cancer, and its expression might identify ERα+ cancers that undergo rapid reprogramming of ERa signaling that is associated with poor outcomes and treatment resistance. Conversely, in ERα− breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. FOXA1 is a downstream target of GATA3 in the mammary gland. Expression in ERα− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment.