Foxk2 Rabbit Polyclonal Antibody (ER2001-47)

UNIPROT #

Q01167

PROTEIN NAME

Foxk2

SYNONYMS

Cellular transcription factor ILF 1 antibody;Cellular transcription factor ILF-1 antibody;Cellular transcription factor ILF1 antibody;Forkhead box K2 antibody;Forkhead box protein K2 antibody;FOX K1 antibody;FOX K2 antibody;FOXK 1 antibody;FOXK 2 antibody;FOXK1 antibody;foxk2 antibody;FOXK2_HUMAN antibody;ILF 1 antibody;ILF antibody;Interleukin enhancer binding factor 1 antibody;Interleukin enhancer-binding factor 1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy . Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context . Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen . Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 . Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate . Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins . In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (By similarity). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (By similarity). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (By similarity). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (By similarity).