GAP43 Recombinant Rabbit Monoclonal Antibody [SC60-06] (ET1610-94)

UNIPROT #

P17677

PROTEIN NAME

GAP43

SYNONYMS

Axonal membrane protein GAP 43 antibody;Axonal membrane protein GAP-43 antibody;B 50 antibody;Calmodulin binding protein P 57 antibody;F1 antibody;GAP 43 antibody;GAP43 antibody;Growth Associated Protein 43 antibody;Growth-associated protein 43 antibody;Nerve Growth Related Peptide antibody;Nerve growth related peptide GAP43 antibody;NEUM_HUMAN antibody;Neural phosphoprotein B 50 antibody;Neural phosphoprotein B-50 antibody;Neuromodulin antibody;Neuron growth associated protein 43 antibody;PP46 antibody;Protein F1 antibody;QtrA-11580 antibody;QtrA-13071 antibody

SEQUENCE SIMILARITIES

Belongs to the neuromodulin family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).; Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.

SUBCELLULAR LOCATION

Cell membrane, growth cone membrane, filopodium membrane, Cytoplasm, synapse, perikaryon, dendrite, axon.

FUNCTION

GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity. The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. GAP43, the consensus choice for its designation, is a nervous system-specific protein that is attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4, though it can exist in the non-bound form in the cytoplasm. This dual sequence enables the association of phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] or PIP2, with actin, facilitating the latter's polymerization thereby regulating neuronal structure. GAP-43 is also a protein kinase C (PKC) substrate. Phosphorylation of serine-41 on GAP-43 by PKC regulates neurite formation, regeneration, and synaptic plasticity.