GOLPH2 Recombinant Rabbit Monoclonal Antibody [JA63-03] (ET1704-64)

UNIPROT #

Q8NBJ4

PROTEIN NAME

GOLPH2

SYNONYMS

bA379P1.3 antibody;C9orf155 antibody;Chromosome 9 open reading frame 155 antibody;Golgi membrane protein 1 antibody;Golgi membrane protein GP73 antibody;Golgi phosphoprotein 2 antibody;Golgi protein 73 kD antibody;Golgi protein 73kD antibody;GOLM 1 antibody;GOLM1 antibody;GOLM1_HUMAN antibody;GOLPH 2 antibody;GOLPH2 antibody;GP 73 antibody;GP73 antibody;PSEC0257 antibody

SEQUENCE SIMILARITIES

Belongs to the GOLM family.

TISSUE SPECIFICITY

Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.; Phosphorylation sites are present in the extracellular medium.

SUBCELLULAR LOCATION

Golgi apparatus.

FUNCTION

GP73 (also known as Golgi phosphoprotein 2, GOLPH 2 or Golgi membrane protein), is a widely expressed, epithelial-specific, type II transmembrane protein which resides in the Golgi apparatus, where it is responsible for the posttranslational modification of proteins produced in the Rough ER while assisting in the transport of proteins through the Golgi. The human GP73 gene has been mapped within a BAC and localized to chromosome 9q21.33. GP73 levels rise in those who have been diagnosed with acute and chronic liver diseases.