Skip to content

Contact

(857) 353-6600

orders@huabio.com

GPX4 Rabbit Polyclonal Antibody (ER1803-15)

Price: Regular price $315.00

Volume

Bulk Order Quote   |   Customization Request

Catalog# ER1803-15

Rabbit Polyclonal to GPX4

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

Select your chosen country/region

Specifications

Product Type

Rabbit polyclonal primary

Product Name

GPX4 Rabbit Polyclonal Antibody (ER1803-15)

Immunogen

Recombinant protein within human gpx4 aa 1-100 / 197.

Host

Rabbit

Positive Control

Rat testis tissue lysate, HepG2, LOVO, MCF-7, mouse testis tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069214

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IF-Cell

  • 1:50-1:100

  • IHC-P

  • 1:50 -1:600

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 22 kDa

Isotype

IgG

TARGET

UNIPROT #

P36969

PROTEIN NAME

GPX4

SYNONYMS

Glutathione peroxidase 4 antibody;GPX 4 antibody;GPX-4 antibody;GPX4 antibody;GPX4_HUMAN antibody;GSHPx-4 antibody;MCSP antibody;mitochondrial antibody;PHGPx antibody;Phospholipid hydroperoxidase antibody;Phospholipid hydroperoxide glutathione peroxidase antibody;Phospholipid hydroperoxide glutathione peroxidase mitochondrial antibody;snGPx antibody;snPHGPx antibody;Sperm nucleus glutathione peroxidase antibody

SEQUENCE SIMILARITIES

Belongs to the glutathione peroxidase family.

TISSUE SPECIFICITY

Present primarily in testis. Expressed in platelets (at protein level).

SUBCELLULAR LOCATION

Cytoplasm. Mitochondrion.

FUNCTION

Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins . Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide . Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species . The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis . The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures . May be required to protect cells from the toxicity of ingested lipid hydroperoxides . Required for normal sperm development and male fertility. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion.

CITATIONS

  • Zhao Jingyuan,et al

    Heme oxygenase-1 is involved in the erastin-induced ferroptosis in acute myeloid leukemia cells

  • H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells

  • Tian, C., Zhao, J., Xiong, Q., Yu, H., & Du, H.

    Secondary iron overload induces chronic pancreatitis and ferroptosis of acinar cells in mice

  • Xia Yu,et al

    Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/mTOR signaling

  • Qilu Fang,et al

    CAPE activates AMPK and Foxo3 signaling to induce growth inhibition and ferroptosis in triple-negative breast cancer

  • Hydroxysafflor yellow A and anhydrosafflor yellow B alleviate ferroptosis and parthanatos in PC12ácells injured by OGD/R

  • Li Xuehui,et al

    Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury

  • Artemisitene Alters LPS-Induced Oxidative stress, inflammation and Ferroptosis in Liver Through Nrf2/HO-1 and NF-kB Pathway

  • Yongjing Zhang,et al

    Corydalis yanhusuo extract and its pharmacological substances alleviate food allergy by inhibiting mast cells activation via PLC/PKC/STAT3 pathway

  • Chen, Y. M., Xu, W., Liu, Y., Zhang, J. H., Yang, Y. Y., Wang, Z. W., Sun, D. J., Li, H., Liu, B., & Chen, L. X.

    Anomanolide C suppresses tumor progression and metastasis by ubiquitinating GPX4-driven autophagy-dependent ferroptosis in triple negative breast cancer

  • Wang H, Guo S, Wang B, et al

    Carnosine attenuates renal ischemia-reperfusion injury by inhibiting GPX4-mediated ferroptosis

  • Li Yong,et al

    A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

  • Zhao Jing,et al

    Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis

Close (esc)

Popup

Use this popup to embed a mailing list sign up form. Alternatively use it as a simple call to action with a link to a product or a page.

Age verification

By clicking enter you are verifying that you are old enough to consume alcohol.

Enter

Search

Main menu

Your cart is currently empty.
Shop now