HP1 alpha Mouse Monoclonal Antibody [B0-1] (M1211-2)

UNIPROT #

P45973

PROTEIN NAME

HP1 alpha

SYNONYMS

Antigen p25 antibody;CBX5 antibody;CBX5_HUMAN antibody;CG8409 antibody;Chromobox 5 antibody;Chromobox homolog 5 (HP1 alpha homolog, Drosophila) antibody;Chromobox homolog 5 antibody;Chromobox protein homolog 5 antibody;Epididymis luminal protein 25 antibody;HEL25 antibody;Heterochromatin protein 1 alpha antibody;Heterochromatin protein 1 antibody;Heterochromatin protein 1 homolog alpha antibody;HP1 alpha antibody;HP1 alpha homolog antibody;HP1 antibody;HP1A antibody;HP1Hs alpha antibody;Su(var)205 antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.; Ubiquitinated.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene. It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called (in humans) HP1α. Heterochromatin protein-1 (HP1) has an N-terminal domain that acts on methylated lysines residues leading to epigenetic repression. The C-terminal of this protein has a chromo shadow-domain (CSD) that is responsible for homodimerizing, as well as interacting with a variety of chromatin-associated, non-histone proteins. HP1α is a highly evolutionary conserved protein, existing in species such a Schizosaccharomyces pombe, a type of yeast, all the way to humans. The N-terminal chromodomain and C-terminal chromoshadow domain appear to be much more conserved (approximately 50-70% amino acid similarity) than the hinge region (approximately 25-30% similarity with the Drosophila HP1 homolog).