Kir6.2 Rabbit Polyclonal Antibody (ER1803-98)

UNIPROT #

Q14654

PROTEIN NAME

Kir6.2

SYNONYMS

ATP sensitive inward rectifier potassium channel 11 antibody;Beta cell inward rectifier subunit antibody;BIR antibody;HHF 2 antibody;HHF2 antibody;IKATP antibody;Inward rectifier K(+) channel Kir6.2 antibody;Inwardly rectifying potassium channel KIR6.2 antibody;IRK 11 antibody;IRK11 antibody;KCNJ11 antibody;Kir 6.2 antibody;Kir6.2 antibody;MGC133230 antibody;PHHI antibody;Potassium channel inwardly rectifing subfamily J member 11 antibody;Potassium channel, inwardly rectifying subfamily J member 11 antibody;Potassium inwardly rectifying channel J11 antibody;TNDM 3 antibody;TNDM3 antibody

SEQUENCE SIMILARITIES

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow Potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive Disfect characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple Alternative spliced ​​transcript variants that encode different protein isoforms have been described for this gene.