Leptin Receptor Recombinant Rabbit Monoclonal Antibody [JA73-01] (ET1704-44)

UNIPROT #

P48357

PROTEIN NAME

Leptin Receptor

SYNONYMS

CD 295 antibody;CD295 antibody;CD295 antigen antibody;Db antibody;Fa antibody;HuB219 antibody;LEP R antibody;LEP-R antibody;LEPR antibody;LEPR_HUMAN antibody;LEPRD antibody;Leptin receptor antibody;Leptin receptor fatty antibody;Leptin receptor gene related protein antibody;Leptin receptor precursor antibody;Leptin receptor precursor antibody;OB R gene related protein antibody;OB receptor antibody;OB-R antibody;OB-RGRP antibody;obl antibody;Obr antibody

SEQUENCE SIMILARITIES

Belongs to the type I cytokine receptor family. Type 2 subfamily.

TISSUE SPECIFICITY

Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus, but also in skeletal muscle. Detected in fundic and antral epithelial cells of the gastric mucosa. Isoform B and isoform A are expressed by NK cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Phosphorylation of Tyr-1079 has a more accessory role.

SUBCELLULAR LOCATION

Cell membrane, Basolateral cell membrane.

FUNCTION

Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.