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MEK2 Recombinant Rabbit Monoclonal Antibody [SD207-08] (ET1612-6)

Price: Regular price $385.00

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Catalog# ET1612-6

Rabbit Monoclonal to MEK2

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • IP

  • FC

Reacts with

  • Human

  • Mouse

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

MEK2 Recombinant Rabbit Monoclonal Antibody [SD207-08] (ET1612-6)

Immunogen

Synthetic peptide within human mek2 aa 1-50/400.

Host

Rabbit

Positive Control

Jurkat cell lysate, Hela cell lysate, 293T cell lysate, Hela, MCF-7, NIH/3T3, human spleen tissue, human breast carcinoma tissue, mouse lung tissue, human liver carcinoma tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SD207-08

RRID

AB_3070134

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • IF-Cell

  • 1:100-1:500

  • IF-Tissue

  • 1:100-1:500

  • IHC-P

  • 1:100-1:500

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 44 kDa

Isotype

IgG

TARGET

UNIPROT #

P36507

PROTEIN NAME

MEK2

SYNONYMS

Cardiofaciocutaneous syndrome antibody;CFC syndrome antibody;CFC4 antibody;Dual specificity mitogen activated protein kinase kinase 2 antibody;Dual specificity mitogen-activated protein kinase kinase 2 antibody;ERK activator kinase 2 antibody;FLJ26075 antibody;MAP kinase kinase 2 antibody;map2k2 antibody;MAPK / ERK kinase 2 antibody;MAPK/ERK kinase 2 antibody;MAPKK 2 antibody;MAPKK2 antibody;MEK 2 antibody;MEK2 antibody;Microtubule associated protein kinase kinase 2 antibody;Mitogen activated protein kinase kinase 2 antibody;Mitogen activated protein kinase kinase 2 p45 antibody;MKK 2 antibody;MKK2 antibody;MP2K2_HUMAN antibody;OTTHUMP00000165826 antibody;OTTHUMP00000165827 antibody;PRKMK 2 antibody;PRKMK2 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

POST-TRANSLATIONAL MODIFICATION

MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).; Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.

SUBCELLULAR LOCATION

Cytoplasm, Membrane.

FUNCTION

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

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