MEK5 Recombinant Rabbit Monoclonal Antibody [SD208-6] (ET1612-34)

UNIPROT #

Q13163

PROTEIN NAME

MEK5

SYNONYMS

Dual specificity mitogen activated protein kinase kinase 5 antibody;Dual specificity mitogen-activated protein kinase kinase 5 antibody;EC 2.7.12.2 antibody;HsT17454 antibody;MAP kinase kinase 5 antibody;MAP kinase kinase MEK5b antibody;MAP2K5 antibody;MAPK/ERK kinase 5 antibody;MAPKK 5 antibody;MAPKK5 antibody;MEK 5 antibody;mitogen-activated protein kinase kinase 5 antibody;MKK5 antibody;MP2K5_HUMAN antibody;PRKMK5 antibody;Protein kinase, mitogen-activated, kinase 5 antibody;SAPKK5 antibody;SKK5 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

TISSUE SPECIFICITY

Expressed in many adult tissues. Abundant in heart and skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.; Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.

SUBCELLULAR LOCATION

Spindle, Cytosol, nucleus, cytoplasm.

FUNCTION

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.