mGluR2 Recombinant Rabbit Monoclonal Antibody [JJ091-09] (ET1701-74)

UNIPROT #

Q14416

PROTEIN NAME

mGluR2

SYNONYMS

AMPA selective glutamate receptor 2 antibody;GLUR2 antibody;GLURB antibody;Glutamate metabotropic receptor 2 antibody;Glutamate receptor homolog antibody;Glutamate receptor metabotropic 2 antibody;GPRC1B antibody;GRM2 antibody;GRM2_HUMAN antibody;Metabotropic glutamate receptor 2 antibody;mGlu2 antibody;mGluR2 antibody;OTTHUMP00000210984 antibody;OTTHUMP00000210986 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 3 family.

TISSUE SPECIFICITY

Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.

SUBCELLULAR LOCATION

Cell membrane, Cell junction, Cell projection.

FUNCTION

The mGluR proteins (metabotropic glutamate receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-2, which may interact with GRASP, acts as a receptor for glutamate. It may also be involved in the regulation of neurotransmission suppression and in synaptogenesis or synaptic stablization.