MGMT Recombinant Rabbit Monoclonal Antibody [JJ089-6] (ET1701-55)

UNIPROT #

P16455

PROTEIN NAME

MGMT

SYNONYMS

6 O methylguanine DNA methyltransferase antibody;6-O-methylguanine-DNA methyltransferase antibody;Agat antibody;AGT antibody;AI267024 antibody;EC 2.1.1.63 antibody;Methylated DNA protein cysteine methyltransferase antibody;Methylated-DNA--protein-cysteine methyltransferase antibody;Methylguanine DNA methyltransferase antibody;MGC107020 antibody;MGMT antibody;MGMT_HUMAN antibody;O 6 methylguanine DNA alkyltransferase antibody;O 6 methylguanine DNA methyltransferase antibody;O-6-methylguanine-DNA methyltransferase antibody;O-6-methylguanine-DNA-alkyltransferase antibody

SEQUENCE SIMILARITIES

Belongs to the MGMT family.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter.