MSH6 Rabbit Polyclonal Antibody (ER30902)

UNIPROT #

P52701

PROTEIN NAME

MSH6

SYNONYMS

DNA mismatch repair protein Msh6 antibody;G/T mismatch binding protein antibody;G/T mismatch-binding protein antibody;GTBP antibody;GTMBP antibody;hMSH6 antibody;HNPCC 5 antibody;HNPCC5 antibody;HSAP antibody;MSH 6 antibody;MSH6 antibody;MSH6_HUMAN antibody;mutS (E. coli) homolog 6 antibody;MutS alpha 160 kDa subunit antibody;MutS homolog 6 (E. coli) antibody;mutS homolog 6 antibody;MutS-alpha 160 kDa subunit antibody;p160 antibody;Sperm associated protein antibody

SEQUENCE SIMILARITIES

Belongs to the DNA mismatch repair MutS family.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked.; Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.

SUBCELLULAR LOCATION

Nucleus, chromosome.

FUNCTION

MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of the human "G/T binding protein," (GTBP) also called p160 or hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair. Defects in hMSH6 are associated with atypical hereditary nonpolyposis colorectal cancer not fulfilling the Amsterdam criteria for HNPCC. hMSH6 mutations have also been linked to endometrial cancer and the development of endometrial carcinomas.