MTAP Rabbit Polyclonal Antibody (ER1901-47)

UNIPROT #

Q13126

PROTEIN NAME

MTAP

SYNONYMS

5' methylthioadenosine phosphorylase antibody;5''-methylthioadenosine phosphorylase antibody;BDMF antibody;c86fus antibody;DMSFH antibody;DMSMFH antibody;Epididymis luminal protein 249 antibody;HEL 249 antibody;LGMBF antibody;MeSAdo phosphorylase antibody;Methylthioadenosine phosphorylase antibody;MSAP antibody;MTA phosphorylase antibody;MTAP antibody;MTAP_HUMAN antibody;MTAPase antibody;S methyl 5 thioadenosine phosphorylase antibody;S methyl 5' thioadenosine phosphorylase antibody;S-methyl-5''-thioadenosine phosphorylase antibody

SEQUENCE SIMILARITIES

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

TISSUE SPECIFICITY

Ubiquitously expressed.

SUBCELLULAR LOCATION

Nucleus, cytoplasm.

FUNCTION

S-methyl-5'-thioadenosine phosphorylase is an enzyme that in humans is encoded by the MTAP gene. This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.