NDRG1 Recombinant Rabbit Monoclonal Antibody [JM32-02] (ET1705-20)

UNIPROT #

Q92597

PROTEIN NAME

NDRG1

SYNONYMS

42 kDa antibody;Anti GC4 antibody;cap43 antibody;cmt4d antibody;Differentiation related gene1 protein antibody;Differentiation-related gene 1 protein antibody;Drg 1 antibody;DRG-1 antibody;drg1 antibody;gc4 antibody;GC4 antibody;antibody;hmsnl antibody;Human mRNA for RTP complete cds antibody;N myc downstream regulated gene 1 antibody;N myc downstream regulated gene 1 protein antibody;N-myc downstream-regulated gene 1 protein antibody;Ndr 1 antibody;ndr1 antibody;NDRG 1 antibody;Ndrg1 antibody;NDRG1 protein antibody;NDRG1_HUMAN antibody;Nickel specific induction protein antibody;Nickel specific induction protein Cap43 antibody;Nickel-specific induction protein Cap43 antibody;nmsl antibody;Nmyc downstream regulated antibody;Nmyc downstream regulated gene1 antibody;Nmyc downstream regulated gene1 protein antibody;Protein NDRG1 antibody;Protein regulated by oxygen 1 antibody;Protein regulated by oxygen1 antibody;Proxy1 antibody;Reduced in tumor antibody;Reducin antibody;Reducing agents and tunicamycin responsive protein antibody;Reducing agents and tunicamycin-responsive protein antibody;Rit42 antibody;RTP antibody;targ1 antibody;TDD5 antibody;tdds antibody;Tunicamycin responsive protein antibody

SEQUENCE SIMILARITIES

Belongs to the NDRG family.

TISSUE SPECIFICITY

Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.

POST-TRANSLATIONAL MODIFICATION

Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus. Cell membrane.

FUNCTION

Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation[citation needed]. Mutations in this gene have been reported to be causative the autosomal-recessive version of Charcot-Marie-Tooth disease known as CMT4D. It has been reported that NDRG1 localizes to the endosomes and is a Rab4a effector involved in vesicular recycling. As reviewed by Fang et al., NDRG1 is involved in embryogenesis and development, cell growth and differentiation, lipid biosynthesis and myelination, stress responses, immunity, DNA repair and cell adhesion among other functions. NDRG1 is localised in the cytoplasm, nucleus and mitochondrion, at probabilities of 47.8%, 26.1% and 8.7%, respectively. In response to DNA damage NDRG1 translocates from the cytoplasm to the nucleus, where it may inhibit cell growth and promote DNA repair mechanisms. It is suggested that NDRG1 acts as a stress response gene or potentially as a transcription factor.