NQO2 Recombinant Rabbit Monoclonal Antibody [SC06-68] (ET1610-92)

UNIPROT #

P16083

PROTEIN NAME

NQO2

SYNONYMS

DHQV antibody;DIA6 antibody;EC 1.10.99.2 antibody;MGC94180 antibody;NAD(P)H dehydrogenase quinone 2 antibody;NAD(P)H menadione oxidoreductase 1 dioxin inducible 2 antibody;NAD(P)H menadione oxidoreductase 2 dioxin inducible antibody;NMOR2 antibody;NQO 2 antibody;NQO2 antibody;NQO2_HUMAN antibody;NRH dehydrogenase [quinone] 2 antibody;NRH dehydrogenase antibody;NRH:quinone oxidoreductase 2 antibody;OTTHUMP00000015948 antibody;OTTHUMP00000015949 antibody;OTTHUMP00000015953 antibody;Ox 2 antibody;Ox2 antibody;QR2 antibody;Quinone antibody;Quinone reductase 2 antibody;Ribosyldihydronicotinamide dehydrogenase [quinone] antibody;Ribosyldihydronicotinamide dehydrogenase antibody

SEQUENCE SIMILARITIES

Belongs to the NAD(P)H dehydrogenase (quinone) family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

NAD(P)H dehydrogenase, quinone 2, also known as QR2, is a protein that in humans is encoded by the NQO2 gene. It is a phase II detoxification enzyme which can carry out two or four electron reductions of quinones. Its mechanism of reduction is through a ping-pong mechanism involving its FAD cofactor. Initially in a reductive phase NQO2 binds to reduced dihydronicotinamide riboside (NRH) electron donor, and mediates a hydride transfer from NRH to FAD. Then, in an oxidative phase, NQO2 binds to its quinone substrate and reduces the quinone to a dihydroquinone. Besides the two catalytic FAD, NQO2 also has two zinc ions. It is not clear whether the metal has a catalytic role. NQO2 is a homodimer. NQO2 can be inhibited by resveratrol. One of QR2's binding sites responds to 2-iodomelatonin, and has been referred to as MT3.