PAX5 Recombinant Rabbit Monoclonal Antibody [PSH06-99] (HA722777)

UNIPROT #

Q02548

PROTEIN NAME

PAX5

SYNONYMS

B cell lineage specific activator antibody;B cell lineage specific activator protein antibody;B cell specific activator protein antibody;B cell specific transcription factor antibody;B-cell-specific transcription factor antibody;BSAP antibody;EBB-1 antibody;KLP antibody;Paired box 5 antibody;Paired box gene 5 (B cell lineage specific activator protein) antibody;Paired box gene 5 (B cell lineage specific activator) antibody;Paired box gene 5 antibody;Paired box homeotic gene 5 antibody;Paired box protein Pax 5 antibody;Paired box protein Pax-5 antibody;Paired domain gene 5 antibody;PAX 5 antibody;PAX5 antibody;PAX5_HUMAN antibody;Transcription factor PAX 5 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Paired box protein Pax-5 is a protein that in humans is encoded by the PAX5 gene. The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.