Phospho-AKT (S473) Recombinant Rabbit Monoclonal Antibody [SY28-05] (ET1607-73)

Tetrahedral framework nucleic acids inhibit pathological neovascularization and vaso-obliteration in ischaemic retinopathy via PI3K/AKT/mTOR signalling pathway

Li, Y., Li, D., You, L., Deng, T., Pang, Q., Meng, X., & Zhu, B.

dCas9-Based PDGFR-β Activation ADSCs Accelerate Wound Healing in Diabetic Mice through Angiogenesis and ECM Remodeling

Dong, J., Guo, C., Yang, Z., Wu, Y., & Zhang, C.

Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens

He Shuai,et al

Neuroprotective Effects of Chlorogenic Acid: Modulation of Akt/Erk1/2 Signaling to Prevent Neuronal Apoptosis in Parkinson's Disease

Hu Jiahe,et al

Engineered-Doping Strategy for Self-Sufficient Reactive Oxygen Species Blossom to Amplify Ferroptosis/Cuproptosis Sensibilization in Hepatocellular Carcinoma Treatment

Apatinib Inhibits Bladder Cancer through Suppression of the VEGFR2-PI3K-AKT Signaling Pathway as Revealed by Network Pharmacology and in vitro Experimental Verification

Dandan Yuan;Mingxing Li

CD44 inhibition attenuates EGFR signaling and enhances cisplatin sensitivity in human EGFR wild-type non-small-cell lung cancer cells

Qin Beibei,et al

TRIM103 activates the RLRs pathway to enhance antiviral response by targeting VP5 and VP7

De Novo Purine Nucleotide Biosynthesis Pathway Is Required for Development and Pathogenicity in Magnaporthe oryzae

Zhiruo Wang ,et al

Zotarolimus alleviates post-trabeculectomy fibrosis via dual functions of anti-inflammation and regulating AMPK/mTOR axis

He, Y., Wang, X., Lu, W., Zhang, D., Huang, L., Luo, Y., Xiong, L., Li, H., Zhang, P., Li, Q., & Liang, S.

PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis

Fan, R., Chen, C., Hu, J., Mu, M., Chuan, D., Chen, Z., Guo, G., & Xu, J.

Multifunctional gold nanorods in low-temperature photothermal interactions for combined tumor starvation and RNA interference therapy

Yue Yaru,et al

Rational formulation of saponin and dexamethasone for the synergistic treatment of rheumatoid arthritis in vivo

Yili Jin,et al

Framework Nucleic Acids Loaded with Quercetin: Protecting Retinal Neurovascular Unit via the Protein Kinase B/Heme Oxygenase-1 Pathway

Yang Yanfang,et al

SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1-involved EMT in hepatocellular carcinoma

Xin H, Tang Y, Jin YH, et al

Knockdown of LMNA inhibits Akt/β-catenin-mediated cell invasion and migration in clear cell renal cell carcinoma cells

Cheng-Ke Xie,et al

Sulindac (K-80003) with nab-paclitaxel and gemcitabine overcomes drug-resistant pancreatic cancer

Cao, X., Shu, Y., Chen, Y., Xu, Q., Guo, G., Wu, Z., Shao, M., Zhou, Y., Chen, M., Gong, Y., Li, C., Shi, Y., & Bu, H.

Mettl14-Mediated m⁶A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cellular and molecular gastroenterology and hepatology, S2352-345X(21)00072-2. Advance online publication.

Zhang, Huihao;Zhou, Chengcong;Zhang, Zhiguo;Yao, Sai;Bian, Yishan;Fu, Fangda;Luo, Huan;Li, Yan;Yan, Shuxin;Ge, Yuying;Chen, Yuying;Zhan, Kunyu;Yue, Ming;Du, Weibin;Tian, Kun;Jin, Hongting;Li, Xiaofeng;Tong, Peijian;Ruan, Hongfeng;Wu, Chengliang

Integration of Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanisms of Zhuanggu Busui Formula Against Osteoporosis

Yang Yuling,et al

Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions

Liu Xinying,et al

Genipin promotes the apoptosis and autophagy of neuroblastoma cells by suppressing the PI3K/AKT/mTOR pathway

Ginsenoside Rk1 Prevents UVB Irradiation-Mediated Oxidative Stress, Inflammatory Response, and Collagen Degradation via the PI3K/AKT/NF-κB Pathway In Vitro and In Vivo

Xia Yu,et al

Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/mTOR signaling

Wang, F., Yang, L., Xiao, M., Zhang, Z., Shen, J., Anuchapreeda, S., Tima, S., Chiampanichayakul, S., & Xiao, Z.

PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathway

Wu Changhong,et al

Berberine attenuates 5-fluorouracil-induced intestinal mucosal injury by modulating the gut microbiota without compromising its anti-tumor efficacy

Yang Xiu,et al

Regulation of Glycolysis-Derived L-lactate Production in Astrocytes Rescues the Memory Deficits and Aβ Burden in Early Alzheimer's Disease Models

He, J., Lin, M., Zhang, X., Zhang, R., Tian, T., Zhou, Y., Dong, W., Yang, Y., Sun, X., Dai, Y., Xu, Y., Zhang, Z., Xu, M., Lei, Q. Y., Xu, Y., & Lv, L.

TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

Miao, T., Peng, C., Tang, Z., Zeng, M., Wang, S., Wang, X., Guo, L., Wang, X., Zhao, J., Zhao, M., Chen, J., & Liu, C.

Implication of Ataxia-Telangiectasia-mutated kinase in epithelium-mesenchyme transition. Carcinogenesis, 42(4), 640–649.

Assessment of the anti-inflammatory mechanism of quercetin 3,7-dirhamnoside using an integrated pharmacology strategy

Jin Mei,et al

Screening and bioinformatics analysis of a potential ceRNA network in melatonin-induced cashmere growth in Liaoning cashmere goats

Li Xin,et al

Exploring the Osteogenic Effects of Simiao Wan through Activation of the PI3K/AKT Pathway in Osteoblasts

Tang, Y., Jin, Y. H., Li, H. L., Xin, H., Chen, J. D., Li, X. Y., & Pan, Y. F.

PBRM1 deficiency oncogenic addiction is associated with activated AKT–mTOR signalling and aerobic glycolysis in clear cell renal cell carcinoma cells

Zhou, S., Zhao, A., Wu, Y., Mi, Y., & Zhang, C.

Protective Effect of Grape Seed Proanthocyanidins on Oxidative Damage of Chicken Follicular Granulosa Cells by Inhibiting FoxO1-Mediated Autophagy

FHL3 promotes pancreatic cancer invasion and metastasis through preventing the ubiquitination degradation of EMT associated transcription factors

Meng, Y., Hu, X., Li, S., Zeng, X., Qiu, L., Wei, M., Wang, Z., & Han, J.

miR-203 inhibits cell proliferation and ERK pathway in prostate cancer by targeting IRS-1. BMC cancer, 20(1), 1028.

Xianlei Han,et al

Network pharmacology and phytochemical composition combined with validation in vivo and in vitro reveal the mechanism of platycodonis radix ameliorating PM2.5-induced acute lung injury

Luo, C., Zhou, M., Chen, C., Li, S., Li, Q., Huang, Y., & Zhou, Z.

A liposome-based combination strategy using doxorubicin and a PI3K inhibitor efficiently inhibits pre-metastatic initiation by acting on both tumor cells and tumor-associated macrophages

Gu, Y., Zhang, N., Zhu, S., Lu, S., Jiang, H., & Zhou, H.

Estradiol reduced 5-HT reuptake by downregulating the gene expression of Plasma Membrane Monoamine Transporter (PMAT, Slc29a4) through estrogen receptor β and the MAPK/ERK signaling pathway

Zhiguang Su

Deficiency in the short-chain acyl-CoA dehydrogenase protects mice against diet-induced obesity and insulin resistance

Huang Z , Dai L, Peng F,et al

mTOR signaling pathway regulates embryonic development and rapid growth of triploid crucian carp

Jian-Li Jiang,Hong-Yong Cu,Zhi-Nan Chen

Hypo-phosphorylated CD147 promotes migration and invasion of hepatocellular carcinoma cells and predicts a poor prognosis. Cellular oncology (Dordrecht), 42(4), 537–554.

Yue Xiao,et al

Dietary oxygenated water mitigates type 2 diabetes mellitus by modulating gut microbiota and enhancing glucose metabolism in skeletal muscle

LncRNA RP11-93B14. 5 promotes gastric cancer cell growth through PI3K/AKT signaling pathway

Rao Zichen

HNRNP I promotes IRAK1 degradation to reduce podocyte apoptosis and inflammatory response alleviating renal injury in diabetic nephropathy

Guo Yingxue,et al

Integrated network pharmacological analysis revealed that Smilax glabra Roxb. alleviates IMQ-induced psoriatic skin inflammation through regulating T cell immune response

Jiang Huangyu,et al

Evodiamine Inhibits the Progression of Esophageal Aquamous Cell Carcinoma via Modulating PI3K/AKT/mTOR Pathway

Chen, X., Wang, J., Song, L., Yu, Y., Shi, M., Jiang, W., Liu, X., & He, X.

Downregulation of fibulin-4 inhibits autophagy and promotes the sensitivity of esophageal squamous cell carcinoma cells to apatinib by activating the Akt-mTOR signaling pathway

Di Guohui,et al

Extracellular Vesicles Containing GAS6 Protect the Liver from Ischemia-Reperfusion Injury by Enhancing Macrophage Efferocytosis via MerTK-ERK-COX2 Signaling

Jingyi Xu,et al

Quercetin inhibited LPS-induced cytokine storm by interacting with the AKT1-FoxO1 and Keap1-Nrf2 signaling pathway in macrophages

Song, X., Liu, B., Zhao, G., Pu, X., Liu, B., Ding, M., & Xue, Y.

Streptococcus pneumoniae promotes migration and invasion of A549 cells in vitro by activating mTORC2/AKT through up-regulation of DDIT4 expression

Han Liu , Haiyang Guo , Yuehan Wu , et al

RCN1 deficiency inhibits oral squamous cell carcinoma progression and THP-1 macrophage M2 polarization

Li, Y., Qu, M., Xing, F., Li, H., Cheng, D., Xing, N., & Zhang, W.

The Protective Mechanism of Dexmedetomidine in Regulating Atg14L-Beclin1-Vps34 Complex Against Myocardial Ischemia-Reperfusion Injury. Journal of cardiovascular translational research, 10.1007/s12265-021-10125-9. Advance online publication.

Yang, S., Zhu, J., Lu, C., Chai, Y., Cao, Z., Lu, J., Zhang, Z., Zhao, H., Huang, Y. Y., Yao, S., Kong, X., Zhang, P., & Wang, X.

Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery

Lin, P., Qiu, F., Wu, M., Xu, L., Huang, D., Wang, C., Yang, X., & Ye, C.

Salvianolic acid B attenuates tubulointerstitial fibrosis by inhibiting EZH2 to regulate the PTEN/Akt pathway

Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway

Carvedilol exhibits anti-acute T lymphoblastic leukemia effect in vitro and in vivo via inhibiting β-ARs signaling pathway

Chen, Y., Lu, Z., Qi, C., Yu, C., Li, Y., Huan, W., Wang, R., Luo, W., Shen, D., Ding, L., Ren, L., Xie, H., Xue, D., Wang, M., Ni, K., Xia, L., Qian, J., & Li, G.

N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma