Phospho-MLKL (S345) Recombinant Rabbit Monoclonal Antibody [JM92-37] (ET1705-51)

UNIPROT #

Q9D2Y4

PROTEIN NAME

Phospho-MLKL (S345)

SYNONYMS

9130019I15Rik antibody;FLJ34389 antibody;hMLKL antibody;Mixed lineage kinase domain like antibody;Mixed lineage kinase domain like protein antibody;Mixed lineage kinase domain like pseudokinase antibody;Mixed lineage kinase domain-like protein antibody;Mlkl antibody;MLKL_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily.

TISSUE SPECIFICITY

Highly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Nucleus.

FUNCTION

Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children.