PI 3 Kinase p110 delta Recombinant Rabbit Monoclonal Antibody [JM83-24] (ET1705-46)

UNIPROT #

O00329

PROTEIN NAME

PI 3 Kinase p110 delta

SYNONYMS

5-bisphosphate 3-kinase 110 kDa catalytic subunit delta antibody;5-bisphosphate 3-kinase catalytic subunit delta isoform antibody;APDS antibody;GRB1 antibody;IMD14 antibody;p110d antibody;p110delta antibody;p110dp85a antibody;p85-ALPHA antibody;Phosphatidylinositol 3 kinase catalytic delta polypeptide antibody;Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform antibody;Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit delta antibody;Phosphatidylinositol 4,5 bisphosphate 3 kinase, catalytic subunit delta antibody;Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform antibody;Phosphatidylinositol-4 antibody;Phosphoinositide 3 kinase B antibody;Phosphoinositide 3 kinase C antibody;Phosphoinositide 3 kinase catalytic delta polypeptide antibody;Phosphoinositide 3 kinase, catalytic, delta polypeptide variant p37delta antibody;PI3 kinase p110 subunit delta antibody;PI3-kinase subunit delta antibody;PI3K antibody;PI3K-delta antibody;PI3Kdelta antibody;Pik3cd antibody;PIK3R1 antibody;PK3CD antibody;PK3CD_HUMAN antibody;PtdIns 3 kinase p110 antibody;PtdIns 3 kinase subunit p110 delta antibody;PtdIns-3-kinase subunit delta antibody;PtdIns-3-kinase subunit p110-delta antibody

SEQUENCE SIMILARITIES

Belongs to the PI3/PI4-kinase family.

TISSUE SPECIFICITY

Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 is expressed predominantly in leukocytes.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene. p110δ regulates immune function. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells). Genetic and pharmacological inactivation of p110δ has revealed that this enzyme is important for the function of T cells, B cell, mast cells and neutrophils. Hence, p110δ is a promising target for drugs that aim to prevent or treat inflammation, autoimmunity and transplant rejection. Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110α, p110β and p110γ. p110α and p110β interact with SH2/SH3-domain-containing p85 adaptor proteins and with GTP-bound Ras.