PI 3 Kinase p85 beta Recombinant Rabbit Monoclonal Antibody [ST04-77] (ET1609-30)

UNIPROT #

O00459

PROTEIN NAME

PI 3 Kinase p85 beta

SYNONYMS

p85 antibody;p85 beta antibody;P85B antibody;P85B_HUMAN antibody;Phosphatidylinositol 3 kinase antibody;Phosphatidylinositol 3 kinase regulatory beta subunit antibody;Phosphatidylinositol 3 kinase regulatory subunit beta antibody;Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 antibody;Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta) antibody;Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta antibody;Phosphatidylinositol 3-kinase regulatory subunit beta antibody;Phosphoinositide 3 kinase regulatory subunit 2 (beta) antibody;Phosphoinositide 3 kinase regulatory subunit 2 antibody;Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta) antibody;Phosphoinositide 3 kinase regulatory subunit polypeptide 2 antibody;Phosphoinositide 3 kinase, regulatory subunit 2 (beta) antibody;Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta) antibody;PI3 kinase p85 beta subunit antibody;PI3 kinase p85 subunit beta antibody;PI3-kinase regulatory subunit beta antibody;PI3-kinase subunit p85-beta antibody;PI3K antibody;PI3K regulatory subunit beta antibody;PIK3R 2 antibody;PIK3R2 antibody;PtdIns 3 kinase p85 beta antibody;PtdIns-3-kinase regulatory subunit beta antibody;PtdIns-3-kinase regulatory subunit p85-beta antibody

SEQUENCE SIMILARITIES

Belongs to the PI3K p85 subunit family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated in response to signaling from activated receptor-type protein kinases. Dephosphorylated by PTPRJ. Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination.; Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.

SUBCELLULAR LOCATION

Cytosol, nucleus

FUNCTION

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110α expression is restricted to white blood cells. It has been shown to bind p85α and p85β, but it apparently does not phosphorylate these subunits. p110α seems to have the capacity to autophosphorylate. p110α does not interact with the p85 subunits. It has been shown to be activated by α and β heterotrimeric G proteins.