Prealbumin Recombinant Rabbit Monoclonal Antibody [JF1016] (ET1702-42)

UNIPROT #

P02766

PROTEIN NAME

Prealbumin

SYNONYMS

Amyloid polyneuropathy antibody;Amyloidosis I antibody;ATTR antibody;Carpal tunnel syndrome 1 antibody;CTS antibody;CTS1 antibody;Dysprealbuminemic euthyroidal hyperthyroxinemia antibody;Dystransthyretinemic hyperthyroxinemia antibody;Epididymis luminal protein 111 antibody;HEL111 antibody;HsT2651 antibody;PALB antibody;Prealbumin amyloidosis type I antibody;Prealbumin antibody;Prealbumin Thyroxine-binding antibody;Senile systemic amyloidosis antibody;TBPA antibody;Thyroxine binding prealbumin antibody;Transthyretin antibody;TTHY_HUMAN antibody;TTR antibody;TTR protein antibody

SEQUENCE SIMILARITIES

Belongs to the transthyretin family.

TISSUE SPECIFICITY

Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.

POST-TRANSLATIONAL MODIFICATION

Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.

SUBCELLULAR LOCATION

Secreted, Cytoplasm.

FUNCTION

Prealbumin, also designated transthyretin, is a major thyroid-hormone binding protein involved in transporting thyroxine from the bloodstream to the brain. Prealbumin is located in the cytoplasm and in the vesicles of developing rat brain cells, and is thought to be transported there from the cerebrospinal fluid via endocytosis. Sequence variants of this protein have been identified in amyloid fibrils from patients with familial amyloidotic polyneuropathy (FAP), the most common form of hereditary systemic amyloidosis. Although the biologically active form of Prealbumin is a tetramer, the amyloidogenic intermed-iate is thought to be a monomeric species. Prealbumin also binds to the retinol carrier protein RBP (retinol-binding protein). The gene encoding Prealbumin maps to human chromosome 18q12.1.