Proteasome 20S LMP7 Recombinant Rabbit Monoclonal Antibody [JB54-32] (ET7107-36)

UNIPROT #

P28062

PROTEIN NAME

Proteasome 20S LMP7

SYNONYMS

ALDD antibody;D6S216 antibody;D6S216E antibody;Large multifunctional peptidase 7 antibody;Large multifunctional protease 7 antibody;LMP 7 antibody;LMP7 antibody;Low molecular mass protein 7 antibody;Low molecular weight protein 7 antibody;Macropain subunit C13 antibody;MGC1491 antibody;Multicatalytic endopeptidase complex subunit C13 antibody;NKJO antibody;OTTHUMP00000062981 antibody;Protease component C13 antibody;Proteasome (prosome macropain) subunit beta type 8 antibody;Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) antibody;Proteasome beta 8 subunit antibody;Proteasome catalytic subunit 3i antibody;Proteasome component C13 antibody;Proteasome related gene 7 antibody;Proteasome subunit beta 5i antibody;Proteasome subunit beta 8 antibody;Proteasome subunit beta type 8 antibody;Proteasome subunit beta type antibody;Proteasome subunit beta type-8 antibody;Proteasome subunit beta-5i antibody;Proteasome subunit Y2 antibody;PSB8_HUMAN antibody;PSMB 8 antibody;PSMB5i antibody;PSMB8 antibody;Really interesting new gene 10 protein antibody;RING 10 antibody;RING10 antibody;Y2 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase T1B family.

DEVELOPMENTAL STAGE

Highly expressed in immature dendritic cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Proteasome subunit beta type-8 as known as 20S proteasome subunit beta-5i is a protein that in humans is encoded by the PSMB8 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Chymotrypsin-like" activity and is capable of cleaving after large hydrophobic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. The constitutive subunit beta1, beta2, and beta 5 (systematic nomenclature) can be replaced by their inducible counterparts beta1i, 2i, and 5i when cells are under the treatment of interferon-γ. The resulting proteasome complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous MHC class-I restricted T cell epitopes.