RYR1 Rabbit Polyclonal Antibody (ER1803-19)

UNIPROT #

P21817

PROTEIN NAME

RYR1

SYNONYMS

Arrhythmogenic right ventricular dysplasia 2 antibody;ARVC2 antibody;ARVD2 antibody;Brain ryanodine receptor calcium release channel antibody;Brain type ryanodine receptor antibody;Cardiac muscle ryanodine receptor calcium release channel antibody;Cardiac muscle type ryanodine receptor antibody;CCO antibody;Central core disease of muscle antibody;HBRR antibody;hRYR 2 antibody;hRYR2 antibody;MHS antibody;MHS1 antibody;Ryanodine receptor 1 (skeletal) antibody;Ryanodine receptor 1 antibody;Ryanodine receptor 2 (cardiac) antibody;Ryanodine receptor 2 antibody;Ryanodine receptor 3 antibody;Ryanodine receptor type1 antibody;RYDR antibody;RYR 1 antibody;RYR 2 antibody;RYR 3 antibody;RYR antibody;RYR-1 antibody;RyR1 antibody;RYR1_HUMAN antibody;RYR2 antibody;RYR3 antibody;Sarcoplasmic reticulum calcium release channel antibody;Skeletal muscle calcium release channel antibody;Skeletal muscle ryanodine receptor antibody;Skeletal muscle type ryanodine receptor antibody;Skeletal muscle-type ryanodine receptor antibody;SKRR antibody;Type 1 like ryanodine receptor antibody;Type 1 ryanodine receptor antibody;VTSIP antibody

SEQUENCE SIMILARITIES

Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily.

TISSUE SPECIFICITY

Skeletal muscle and brain (cerebellum and hippocampus).

POST-TRANSLATIONAL MODIFICATION

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843.; Activated by reversible S-nitrosylation (By similarity). Repeated very high-level exercise increases S-nitrosylation.

SUBCELLULAR LOCATION

Sarcoplasmic reticulum membrane.

FUNCTION

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.