SERCA2 Recombinant Rabbit Monoclonal Antibody [JM10-20] (ET1703-01)

UNIPROT #

P16615

PROTEIN NAME

SERCA2

SYNONYMS

AT2A2_HUMAN antibody;Atp2a2 antibody;ATP2B antibody;ATPase Ca++ transporting cardiac muscle slow twitch 2 antibody;Calcium pump 2 antibody;Calcium-transporting ATPase sarcoplasmic reticulum type antibody;Calcium-transporting ATPase sarcoplasmic reticulum type slow twitch skeletal muscle isoform antibody;Cardiac Ca2+ ATPase antibody;DAR antibody;DD antibody;Endoplasmic reticulum class 1/2 Ca(2+) ATPase antibody;MGC45367 antibody;Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 antibody;SERCA 2 antibody;SERCA2 antibody;serca2a antibody;slow twitch skeletal muscle isoform antibody;SR Ca(2+)-ATPase 2 antibody

SEQUENCE SIMILARITIES

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.

TISSUE SPECIFICITY

Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart.

POST-TRANSLATIONAL MODIFICATION

Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Sarcoplasmic reticulum membrane.

FUNCTION

ATP2A2 also known as sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is an ATPase associated with Darier's disease and Acrokeratosis verruciformis. This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.