smooth muscle Myosin heavy chain 11 Recombinant Rabbit Monoclonal Antibody

Function

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4.

Background References

1. Boreham MK, Miller RT, Schaffer JI, Word RA. Smooth muscle myosin heavy chain and caldesmon expression in the anterior vaginal wall of women with and without pelvic organ prolapse. Am J Obstet Gynecol. 2001 Oct;185(4):944-5doi: 10.1067/mob.2001.11734PMID: 11641683.

2. Li M, Li S, Rao Y, Cui S, Gou K. Loss of smooth muscle myosin heavy chain results in the bladder and stomach developing lesion during foetal development in mice. J Genet. 2018 Jun;97(2):469-475. PMID: 29932067.

Subcellular Location

Melanosome.

UNIPROT

SwissProt: P35749 Human

Synonyms