smooth muscle Myosin heavy chain 11 Recombinant Rabbit Monoclonal Antibody
Catalog# IRS176RB
smooth muscle Myosin heavy chain 11 Recombinant Rabbit Monoclonal Antibody
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mIHC
-
Human
-
unconjugated
Overview
Product Name
smooth muscle Myosin heavy chain 11 Recombinant Rabbit Monoclonal Antibody
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within human smooth muscle Myosin heavy chain 11 aa 1-50 / 1,972.
Species Reactivity
Human
Validated Applications
mIHC
Target Molecular Weight
Predicted band size: 227 kDa
Positive Control
Human tonsil tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
mIHC
-
1:100
Target
Function
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4.
Background References
1. Boreham MK, Miller RT, Schaffer JI, Word RA. Smooth muscle myosin heavy chain and caldesmon expression in the anterior vaginal wall of women with and without pelvic organ prolapse. Am J Obstet Gynecol. 2001 Oct;185(4):944-5doi: 10.1067/mob.2001.11734PMID: 11641683.
2. Li M, Li S, Rao Y, Cui S, Gou K. Loss of smooth muscle myosin heavy chain results in the bladder and stomach developing lesion during foetal development in mice. J Genet. 2018 Jun;97(2):469-475. PMID: 29932067.
Subcellular Location
Melanosome.
UNIPROT
Synonyms
AAT4 antibody
DKFZp686D10126 antibody
DKFZp686D19237 antibody
FAA4 antibody
FLJ35232 antibody
MGC126726 antibody
MGC32963 antibody
MYH 11 antibody
MYH11 antibody
MYH11_HUMAN antibody
ExpandImages
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mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-smooth muscle Myosin heavy chain 11 antibody (IRS176RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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smooth muscle Myosin heavy chain 11 Recombinant Rabbit Monoclonal Antibody [JE60-21]
Application: WB,IHC-P,mIHC,IF-Tissue
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
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Application: WB,IHC-P,IF-Cell,IF-Tissue,FC
Reactivity: Human,Rat
Conjugate: unconjugated
