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SPATA13 Rabbit Polyclonal Antibody (ER1902-32)

Price: Regular price $315.00

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Catalog# ER1902-32

Rabbit Polyclonal to SPATA13

Tested for

  • WB

  • IHC-P

  • FC

Reacts with

  • Human

  • Rat

  • Mouse

Specifications

Product Type

Rabbit polyclonal primary

Product Name

SPATA13 Rabbit Polyclonal Antibody (ER1902-32)

Immunogen

Recombinant protein within human spata13 aa 423-572 / 652.

Host

Rabbit

Positive Control

Rat kidney tissue lysates, rat testis tissue, human colon cancer tissue, human kidney tissue, SHSY5Y.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069417

APPLICATION DILUTION

  • WB

  • 1:500

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 75 kDa

Isotype

IgG

TARGET

UNIPROT #

Q96N96

PROTEIN NAME

SPATA13

SYNONYMS

APC-stimulated guanine nucleotide exchange factor 2 antibody;ARHGEF29 antibody;Asef2 antibody;FLJ31208 antibody;RP11-307N16.3 antibody;Spata13 antibody;Spermatogenesis-associated protein 13 antibody;SPT13_HUMAN antibody

TISSUE SPECIFICITY

Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors.

SUBCELLULAR LOCATION

Cell membrane, Cell projection, Cytoplasm, Membrane.

FUNCTION

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

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