STAT2 Recombinant Rabbit Monoclonal Antibody [JF0884] (ET1702-18)

UNIPROT #

P52630

PROTEIN NAME

STAT2

SYNONYMS

Homo sapiens interferon alpha induced transcriptional activator antibody;interferon alpha induced transcriptional activator antibody;ISGF 3 antibody;ISGF3 antibody;MGC59816 antibody;P113 antibody;signal transducer and activator of transcription 2 113kD antibody;Signal transducer and activator of transcription 2 antibody;STAT113 antibody;Stat2 antibody;STAT2_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the transcription factor STAT family.

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.; 'Lys-48'-linked ubiquitination by DCST1 leads to STAT2 proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs).STAT2 sequence identity between mouse and human is only 68%.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to IFN, this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9) and form ISGF-3 (IFN-stimulated gene factor-3), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly.[9] ISGF-3 proceeds the activation of genes via the IFN-stimulated response element (ISRE). ISRE-driven genes include Ly-6C, the double-stranded RNA kinase (PKR), 2´ to 5´ oligoadenylate synthase (OAS), MX and potentially MHC class I.[Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. STAT2 knockout mice are unresponsive to type I IFN and extremely vulnerable to viral infection. They indicate the loss of the type I IFN autocrine loop and several defects in macrophages and T cell responses. Stat2-/- cells show differences in the biological response to IFN-α.