Synaptophysin Rabbit Polyclonal Antibody (0407-2)

UNIPROT #

P08247

PROTEIN NAME

Synaptophysin

SYNONYMS

Major synaptic vesicle protein p38 antibody;MRX96 antibody;MRXSYP antibody;Syn p38 antibody;Synaptophysin antibody;Syp antibody;SYPH antibody;SYPH_HUMAN antibody;SypI antibody

SEQUENCE SIMILARITIES

Belongs to the synaptophysin/synaptobrevin family.

TISSUE SPECIFICITY

Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasmic vesicle, Membrane, Synapse, Synaptosome.

FUNCTION

Synaptophysin is a 38 kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms.