Syntaxin 3 Recombinant Rabbit Monoclonal Antibody [JE40-96] (ET7109-19)

UNIPROT #

Q13277

PROTEIN NAME

Syntaxin 3

SYNONYMS

FLJ30906 antibody;Stx3 antibody;STX3_HUMAN antibody;STX3A antibody;Syntaxin 3A antibody;Syntaxin-3 antibody

SEQUENCE SIMILARITIES

Belongs to the syntaxin family.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Correct vesicular transport is essential to the survival of eukaryotic cells. This process is determined by specific pairing of vesicle-associated SNAREs (v-SNAREs) with those on the target membrane (t-SNAREs). This complex then recruits soluble NSF attachment proteins (SNAPs) and N-ethylmaleimide-sensitive factor (NSF) to form the highly stable SNAP receptor (SNARE) complex. The formation of a SNARE complex pulls the vesicle and target membrane together and may provide the energy to drive fusion of the lipid bilayers. Syntaxins, a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane, display broad tissue distribution and contain carboxy-terminal hydrophobic domains that direct themselves to their respective intracellular compartments. Syntaxin 3 localizes to the apical plasma membrane and is involved in membrane fusion of apical trafficking pathways. Syntaxin 3 is a key factor in the growth of neurites, and it also functions as a direct target for arachidonic acid. Human Syntaxin 3 has two forms: Syntaxin 3A and 3B, while the mouse version has four forms: 3A, 3B, 3C, and 3D.