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TOMM20 Recombinant Rabbit Monoclonal Antibody [ST04-72] (ET1609-25)

Price: Regular price $385.00

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Catalog# ET1609-25

Rabbit Monoclonal to TOMM20

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • IP

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

TOMM20 Recombinant Rabbit Monoclonal Antibody [ST04-72] (ET1609-25)

Immunogen

Recombinant protein within human tomm20 aa 1-145 / 145.

Host

Rabbit

Positive Control

HeLa cell lysate, Saos-2 cell lysate, HepG2 cell lysate, A549 cell lysate, NIH/3T3 cell lysate, C2C12 cell lysate, C6 cell lysate, PC-12 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, HepG2, MCF7 cell lysate, F9 cell lysate, rat lung tissue lysate, NIH/3T3, human liver carcinoma tissue, human kidney tissue, mouse kidney tissue, mouse small intestine tissue, mouse heart tissue, rat large intestine tissue, human liver tissue, HeLa.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

ST04-72

RRID

AB_3069837

APPLICATION DILUTION

  • WB

  • 1:2,000

  • IF-Cell

  • 1:1,000

  • IHC-P

  • 1:800

  • IF-Tissue

  • 1:200

  • FC

  • 1:1,000

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 16 kDa

Isotype

IgG

TARGET

UNIPROT #

Q15388

PROTEIN NAME

TOMM20

SYNONYMS

KIAA0016 antibody;MAS20 antibody;MGC117367 antibody;Mitochondrial 20 kDa outer membrane protein antibody;Mitochondrial import receptor subunit TOM20 homolog antibody;MOM19 antibody;Outer mitochondrial membrane receptor Tom20 antibody;TOM20 antibody;TOM20_HUMAN antibody;TOMM20 antibody;Translocase of outer mitochondrial membrane 20 homolog (yeast) antibody;Translocase of outer mitochondrial membrane 20 homolog type II antibody

SEQUENCE SIMILARITIES

Belongs to the Tom20 family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

SUBCELLULAR LOCATION

Mitochondrion outer membrane.

FUNCTION

The mitochondrial preprotein translocases of the outer membrane (Tom) is a multisubunit protein complex that facilitates the import of nucleus-encoded precursor proteins across the mitochondrial outer membrane. The Tom machinery consists of import receptors for the initial binding of cytosolically synthesized preproteins and a general import pore (GIP) for the membrane translocation of various preproteins into the mitochondria. The import receptors include Tom20 and Tom22, which form a heteromeric receptor complex that initiates the insertion of newly synthesized proteins into the outer membrane and then directs the precursor protein into the GIP. In yeast, Tom22 is the essential component of the import receptor complex as it functions as both a receptor for the preproteins and serves as a docking point for both Tom20 and the GIP. Tom22 directly associates with Tom40, the major component of the GIP, and thereby forms a stable interaction between the two core complexes to facilitate the fluid movement of preproteins into the mitochondria. The insertion of Tom40 into the Tom machinery requires the initial binding of Tom40 to Tom20 and leads to the efficient incorporation of Tom40 precursors into preexisting Tom complexes.

CITATIONS

  • Dong, J., Guo, C., Yang, Z., Wu, Y., & Zhang, C.

    Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens

  • Zhou, Y., Long, D., Zhao, Y., Li, S., Liang, Y., Wan, L., Zhang, J., Xue, F., & Feng, L.

    Oxidative stress-mediated mitochondrial fission promotes hepatic stellate cell activation via stimulating oxidative phosphorylation

  • Yu L, Qi S, Wei G, et al

    Krüppel-like factor 5 activates chick intestinal stem cell and promotes mucosal repair after impairment

  • Lei, Y., Zhang, X., Xu, Q., Liu, S., Li, C., Jiang, H., Lin, H., Kong, E., Liu, J., Qi, S., Li, H., Xu, W., & Lu, K.

    Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility

  • Ren Yanlin,et al

    Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction

  • Min Yang,et al

    Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice

  • Di Wang

    Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation

  • Zhang, X., Yang, Z., Pan, T., Long, X., Sun, Q., Wang, P. H., Li, X., & Kuang, E.

    SARS-CoV-2 ORF3a induces RETREG1/FAM134B dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection

  • Physiological and transcriptomic analyses reveal the toxicological mechanism and risk assessment of environmentally-relevant waterborne tetracycline exposure on the gills of tilapia (Oreochromis niloticus)

  • Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway

  • Zhang, J., Yu, Q., Jiang, D., Yu, K., Yu, W., Chi, Z., Chen, S., Li, M., Yang, D., Wang, Z., Xu, T., Guo, X., Zhang, K., Fang, H., Ye, Q., He, Y., Zhang, X., & Wang, D.

    Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation

  • Xu, T., Yu, W., Fang, H., Wang, Z., Chi, Z., Guo, X., Jiang, D., Zhang, K., Chen, S., Li, M., Guo, Y., Zhang, J., Yang, D., Yu, Q., Wang, D., & Zhang, X.

    Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation

  • Jiaxi Liu,et al

    Edwardsiella piscicida promotes mitophagy to escape autophagy-mediated antibacterial defense in teleost monocytes/macrophages

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