TREX1 Recombinant Rabbit Monoclonal Antibody [JG35-71] (ET7108-16)

UNIPROT #

Q9NSU2

PROTEIN NAME

TREX1

SYNONYMS

3' 5' exonuclease TREX1 antibody;3' repair exonuclease 1 antibody;AGS1 antibody;AGS5 antibody;CRV antibody;Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody;DKFZp434J0310 antibody;DNase III antibody;DRN3 antibody;HERNS antibody;Three prime repair exonuclease 1 antibody;TREX1 antibody

SEQUENCE SIMILARITIES

Belongs to the exonuclease superfamily. TREX family.

TISSUE SPECIFICITY

Detected in thymus, spleen, liver, brain, heart, small intestine and colon.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated, but not targeted to proteasomal degradation. Ubiquitination may be important for interaction with UBQLN1.

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus.

FUNCTION

Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.