TRIM33 Rabbit Polyclonal Antibody (HA500475)

UNIPROT #

Q9UPN9

PROTEIN NAME

TRIM33

SYNONYMS

8030451N04Rik antibody;AI413936 antibody;cb1085 antibody;DKFZp586K1123 antibody;E3 ubiquitin-protein ligase TRIM33 antibody;EC 6.3.2.- antibody;Ectodermin antibody;Ectodermin homolog antibody;FLJ11429 antibody;FLJ32925 antibody;id:ibd2175 antibody;MGC136680 antibody;mKIAA1113 antibody;OTTHUMP00000013662 antibody;OTTHUMP00000013663 antibody;Protein Rfg7 antibody;PTC7 antibody;Ret fused gene 7 antibody;RET-fused gene 7 protein antibody;RFG7 antibody;Rfg7 protein antibody;TF1G antibody;TIF1 gamma antibody;TIF1-gamma antibody;TIF1G antibody;TIF1GAMMA antibody;TIFGAMMA antibody;Transcription intermediary factor 1-gamma antibody;Transcriptional intermediary factor 1 gamma antibody;TRI33_HUMAN antibody;trim33 antibody;Tripartite motif containing 33 antibody;Tripartite motif containing 33 protein antibody;tripartite motif-containing 33 antibody;Tripartite motif-containing protein 33 antibody;wu:fc17f10 antibody;zgc:136680 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.