TXNRD1 Recombinant Rabbit Monoclonal Antibody [JA11-32] (ET1704-81)

UNIPROT #

Q16881

PROTEIN NAME

TXNRD1

SYNONYMS

cytoplasmic antibody;Gene associated with retinoic and IFN-induced mortality 12 protein antibody;Gene associated with retinoic and interferon-induced mortality 12 protein antibody;Gene associated with retinoid IFN induced mortality 12 protein antibody;GRIM 12 antibody;GRIM-12 antibody;GRIM12 antibody;KDRF antibody;KM 102 derived reductase like factor antibody;KM-102-derived reductase-like factor antibody;MGC9145 antibody;Oxidoreductase antibody;Thioredoxin reductase 1 antibody;Thioredoxin reductase 1 cytoplasmic antibody;Thioredoxin reductase GRIM 12 antibody;Thioredoxin reductase TR1 antibody;TR 1 antibody;TR antibody;TR1 antibody;TRXR 1 antibody;TRXR1 antibody;TRXR1_HUMAN antibody;TXNR antibody;TXNRD 1 antibody;Txnrd1 antibody

SEQUENCE SIMILARITIES

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

TISSUE SPECIFICITY

Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.

POST-TRANSLATIONAL MODIFICATION

The N-terminus of isoform 5 is blocked.; ISGylated.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx reductases (TrxR1 and TrxR2) are ubiquitous Ly noble flavoproteins that catalyze the NADPH-dependent reduction of Trx as well as several other oxidized cellular components. Mammalian Trx reductases are a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val- Asn-Val-Gly-Cys. TrxR1 and TrxR2 are also involved in the prevention of oxidative stress. Inhibition of TrxR activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.