uPA Receptor Mouse Monoclonal Antibody [A6E8]

Function

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

Background References

1. Li J. et. al. Prognostic Significance and Gene Co-Expression Network of PLAU and PLAUR in Gliomas. Front Oncol. 2022 Jan

2. Liu M. et. al. PLAUR as a Potential Biomarker Associated with Immune Infiltration in Bladder Urothelial Carcinoma. J Inflamm Res. 2021 Sep

Subcellular Location

Cell membrane, invadopodium membrane; Secreted.

UNIPROT

SwissProt: Q03405 Human

Synonyms