WNT2 Rabbit Polyclonal Antibody (ER1511-4)
Catalog# ER1511-4
Rabbit Polyclonal to WNT2
-
WB
-
FC
-
Human
-
Mouse
Positive control:
Lane 1: PC-3M cell lysate
Lane 2: Mouse brain tissue
Lane 3: Jurkat cell lysate
Lane 4: Human lung tissue
Specifications
Product Type
Rabbit polyclonal primary
Product Name
WNT2 Rabbit Polyclonal Antibody (ER1511-4)
Immunogen
Synthetic peptide within human wnt2 aa 209-263.
Host
Rabbit
Positive Control
PC-3M cell lysate, Mouse brain tissue, Jurkat cell lysate, Human lung tissue, Jurkat.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
-
WB
-
1:1,000-1:2,000
-
FC
-
1:100-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 40 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
WNT2
SYNONYMS
Int 1 related protein antibody;Int-1-like protein 1 antibody;Int-1-related protein antibody;INT1L 1 antibody;INT1L1 antibody;IRP antibody;IRP protein antibody;ONCOGENE INT1 LIKE 1 antibody;Protein Wnt-2 antibody;Secreted growth factor antibody;Wingless type MMTV integration site family member 2 antibody;WNT 2 antibody;WNT2 antibody;WNT2_HUMAN antibody
SEQUENCE SIMILARITIES
Belongs to the Wnt family.
TISSUE SPECIFICITY
Expressed in brain in the thalamus, in fetal and adult lung and in placenta.
POST-TRANSLATIONAL MODIFICATION
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
SUBCELLULAR LOCATION
Secreted, Extracellular matrix.
FUNCTION
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons.
