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Glucose Transporter GLUT1 Recombinant Rabbit Monoclonal Antibody [SA0377] (ET1601-10)

Price: Regular price $385.00

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Catalog# ET1601-10

Rabbit Monoclonal to Glucose Transporter GLUT1

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Glucose Transporter GLUT1 Recombinant Rabbit Monoclonal Antibody [SA0377] (ET1601-10)

Immunogen

Synthetic peptide within human glut1 aa 443-492 / 492.

Host

Rabbit

Positive Control

HeLa cell lysate, PC-12 cell lysate, HeLa, HT-29 cell lysate, HepG2 cell lysate, NIH/3T3 cell lysate, L-929 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, Jurkat, NIH/3T3, C6, human liver tissue, human placenta tissue, human liver carcinoma tissue, human kidney tissue, mouse liver tissue, mouse kidney tissue, HepG2, human lung cancer tissue, human liver tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SA0377

RRID

AB_2941981

APPLICATION DILUTION

  • WB

  • 1:50,000-1:100,000

  • IF-Cell

  • 1:500-1:1,000

  • IHC-P

  • 1:5,000-1:10,000

  • IF-Tissue

  • 1:500-1:1,000

  • FC

  • 1:500-1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 54 kDa

Isotype

IgG

TARGET

UNIPROT #

P11166

PROTEIN NAME

Glucose Transporter GLUT1

SYNONYMS

Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity) antibody;CSE antibody;DYT17 antibody;DYT18 antibody;DYT9 antibody;EIG12 antibody;erythrocyte/brain antibody;Erythrocyte/hepatoma glucose transporter antibody;facilitated glucose transporter member 1 antibody;Glucose transporter 1 antibody;Glucose transporter type 1 antibody;Glucose transporter type 1, erythrocyte/brain antibody;GLUT antibody;GLUT-1 antibody;GLUT1 antibody;GLUT1DS antibody;GLUTB antibody;GT1 antibody;GTG1 antibody;Gtg3 antibody;GTR1_HUMAN antibody;HepG2 glucose transporter antibody;HTLVR antibody;Human T cell leukemia virus (I and II) receptor antibody;MGC141895 antibody;MGC141896 antibody;PED antibody;RATGTG1 antibody;Receptor for HTLV 1 and HTLV 2 antibody;SLC2A1 antibody;Solute carrier family 2 (facilitated glucose transporter), member 1 antibody;Solute carrier family 2 antibody;Solute carrier family 2, facilitated glucose transporter member 1 antibody

SEQUENCE SIMILARITIES

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

TISSUE SPECIFICITY

Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.

SUBCELLULAR LOCATION

Cell membrane, Melanosome

FUNCTION

Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene. GLUT1 facilitates the transport of glucose across the plasma membranes of mammalian cells. This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. One good source of GLUT1 is erythrocyte membranes. GLUT1 accounts for 2 percent of the protein in the plasma membrane of erythrocytes. GLUT1, found in the plasma membrane of erythrocytes, is a classic example of a uniporter. After glucose is transported into the erythrocyte, it is rapidly phosphorylated, forming glucose-6-phosphate, which cannot leave the cell. Mutations in this gene can cause GLUT1 deficiency syndrome 1, GLUT1 deficiency syndrome 2, idiopathic generalized epilepsy 12, dystonia 9, and stomatin-deficient cryohydrocytosis.

CITATIONS

  • Zhou Jian,et al

    Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation

  • Autophagy participates in germline cyst breakdown and follicular formation by modulating glycolysis switch via Akt signaling in newly-hatched chicken ovaries

  • Liu, Y., Chen, Y., Wang, Y., Jiang, S., Lin, W., Wu, Y., Li, Q., Guo, Y., Liu, W., & Yuan, Q.

    DNA demethylase ALKBH1 promotes adipogenic differentiation via regulation of HIF-1 signaling

  • Gao, F., Liang, T., Lu, Y. W., Fu, X., Dong, X., Pu, L., Hong, T., Zhou, Y., Zhang, Y., Liu, N., Zhang, F., Liu, J., Malizia, A. P., Yu, H., Zhu, W., Cowan, D. B., Chen, H., Hu, X., Mably, J. D., Wang, J., … Chen, J.

    A defect in mitochondrial protein translation influences mitonuclear communication in the heart

  • Lu-Sha Cen,et al

    Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds

  • Cui Aimin,et al

    Low-level laser therapy alleviates periodontal age-related inflammation in diabetic mice via the GLUT1/mTOR pathway

  • Activation of AMPK pathway compromises Rab11 downregulation-mediated inhibition of Schwann cell proliferation in a Glut1 and Glut3-dependent manner

  • Yang, F., Zhou, L., Shen, Y., Zhao, S., Zheng, Y., Men, R., Fan, X., & Yang, L.

    Metabolic heterogeneity caused by HLA-DRB1*04:05 and protective effect of inosine on autoimmune hepatitis

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