SHIP Recombinant Rabbit Monoclonal Antibody [SY11-08] (ET1605-30)

UNIPROT #

Q92835

PROTEIN NAME

SHIP

SYNONYMS

Inositol polyphosphate 5 phosphatase of 145kDa antibody;4 antibody;5-trisphosphate 5-phosphatase 1 antibody;hp51CN antibody;Inositol polyphosphate 5 phosphatase 145kDa antibody;Inositol polyphosphate 5 phosphatase antibody;Inositol polyphosphate-5-phosphatase of 145 kDa antibody;INPP5D antibody;MGC104855 antibody;MGC142140 antibody;MGC142142 antibody;p150Ship antibody;Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody;Phosphatidylinositol-3 antibody;SH2 containing inositol phosphatase isoform b antibody;SH2 domain containing inositol 5' phosphatase 1 antibody;SH2 domain containing inositol phosphatase 1 antibody;SH2 domain-containing inositol phosphatase 1 antibody;SH2 domain-containing inositol-5'-phosphatase 1 antibody;SHIP-1 antibody;SHIP1 antibody;SHIP1_HUMAN antibody;Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody;SIP-145 antibody;SIP145 antibody

SEQUENCE SIMILARITIES

Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

TISSUE SPECIFICITY

Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.

SUBCELLULAR LOCATION

Cytoskeleton, Cell membrane, Cytoplasm, Membrane raft, Membrane.

FUNCTION

The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and mapped to band q34 on chromosome 5, and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.