YY1 Recombinant Rabbit Monoclonal Antibody [SY29-01] (ET1605-40)

UNIPROT #

P25490

PROTEIN NAME

YY1

SYNONYMS

CF1 antibody;Delta antibody;Delta transcription factor antibody;INO80 complex subunit S antibody;INO80S antibody;NF E1 antibody;NF-E1 antibody;NFE1 antibody;OTTHUMP00000197459 antibody;Transcriptional repressor protein YY1 antibody;TYY1_HUMAN antibody;UCR motif DNA binding protein antibody;UCRBP antibody;Yin and yang 1 antibody;Yin and Yang 1 protein antibody;Yin Yang 1 antibody;Ying Yang 1 antibody;YY 1 antibody;YY 1 transcription factor antibody;YY-1 antibody;YY1 antibody;YY1 transcription factor antibody

SEQUENCE SIMILARITIES

Belongs to the YY transcription factor family.

POST-TRANSLATIONAL MODIFICATION

Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites.; Ubiquitinated.

SUBCELLULAR LOCATION

Nucleus matrix.

FUNCTION

The YY1 transcription factor, also known as NF-E1 (human) and Delta or UCRBP (mouse) is of interest due to its diverse effects on a wide variety of target genes. YY1 is broadly expressed in a wide range of cell types and contains four C-terminal zinc finger motifs of the Cys-Cys-His-His type and an unusual set of structural motifs at its N-terminal. It binds to downstream elements in several vertebrate ribosomal protein genes, where it apparently acts positively to stimulate transcription and can act either negatively or positively in the context of the immunoglobulin k 3' enhancer and immunoglobulin heavy-chain μE1 site as well as the P5 promoter of the adeno-associated virus. It thus appears that YY1 is a bifunctional protein, capable of functioning as an activator in some transcriptional control elements and a repressor in others.