14-3-3 alpha+beta Rabbit Polyclonal Antibody

Function

The 14-3-3 proteins are a family of proteins involved in the regulation of apoptosis, mitogenic signaling and cell-cycle checkpoints. The 14-3-3 proteins are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. Through binding Bad, 14-3-3 prevents apoptosis by sequestering Bad to the cytosol. The 14-3-3 proteins are also Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. They bind to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Background References

1. Carninci P., Kasukawa T., et al. Science 309:1559-1563(2005).

2. Sacksteder C.A., Qian W.-J.,et al. Biochemistry 45:8009-8022(2006).

3. Fu, H., et al. 14-3-3 proteins: structure, function, and regulation. Ann. Rev. Pharmacol. Toxicol. 40: 617–47 (2000).

Sequence Similarity

Belongs to the 14-3-3 family.

Post-translational Modification

Isoform alpha differs from isoform beta in being phosphorylated (By similarity). Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.; Isoform Short contains a N-acetylmethionine at position 1.

Subcellular Location

Cytoplasm, Melanosome.

UNIPROT

SwissProt: P31946 Human

SwissProt: Q9CQV8 Mouse

Synonyms