GM-CSF-R-alpha (CD116) Rabbit Polyclonal Antibody (0804-8)

UNIPROT #

Q00941

PROTEIN NAME

GM-CSF-R-alpha (CD116)

SYNONYMS

CD_antigen=CD116 antibody;CD116 antibody;CD116 antigen antibody;CDw116 antibody;Colony stimulating factor 2 receptor alpha chain antibody;Colony stimulating factor 2 receptor alpha low affinity antibody;Colony stimulating factor 2 receptor alpha subunit antibody;CSF 2R antibody;CSF2R antibody;CSF2R_HUMAN antibody;CSF2RA antibody;CSF2RAX antibody;CSF2RAY antibody;CSF2RX antibody;CSF2RY antibody;GM CSF R alpha antibody;GM CSF receptor alpha subunit antibody;GM-CSF-R-alpha antibody;GMCSFR antibody;GMCSFR-alpha antibody;GMR-alpha antibody;Granulocyte macrophage colony stimulating factor receptor alpha chain antibody;Granulocyte-macrophage colony-stimulating factor receptor subunit alpha antibody;SMDP4 antibody

SEQUENCE SIMILARITIES

Belongs to the type I cytokine receptor family. Type 5 subfamily.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The granulocyte-macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells. In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development. The receptor is primarily located on neutrophils, eosinophils and monocytes/macrophages, it is also on CD34+ progenitor cells (myeloblasts) and precursors for erythroid and megakaryocytic lineages, but only in the beginning of their development. It is associated with Surfactant metabolism dysfunction type 4.