CCL3 / MIP-1 alpha Rabbit Polyclonal Antibody

Function

Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1α, MIP-1β, MIP-2, MIP-3α, MIP-3β, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1β is more selective than MIP-1α, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1α is a more potent lymphocyte chemoattractant than MIP-1β and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1α has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1β and RANTES

Background References

1. Wong L et al. Experimental autoimmune prostatitis induces microglial activation in the spinal cord. Prostate 75:50-9 (2015).

2. Tripathy D & Grammas P Acetaminophen protects brain endothelial cells against oxidative stress. Microvasc Res 77:289-96 (2009).

Sequence Similarity

Belongs to the intercrine beta (chemokine CC) family.

Tissue Specificity

Expressed in lung, spleen, and pancreas.

Subcellular Location

Secreted

UNIPROT

SwissProt: P10147 Human

SwissProt: P10855 Mouse

SwissProt: P50229 Rat

Synonyms