CCL3 / MIP-1 alpha Rabbit Polyclonal Antibody

Function

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene. CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5. CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.

Background References

1. Sheng D et al. Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization. J Immunother Cancer. 2022 May

2. Yang YL et al. The Role of CCL3 in the Pathogenesis of Rheumatoid Arthritis. Rheumatol Ther. 2023 Aug

Sequence Similarity

Belongs to the intercrine beta (chemokine CC) family.

Tissue Specificity

Expressed in lung, spleen, and pancreas.

Subcellular Location

Secreted.

UNIPROT

SwissProt: P10147 Human

Synonyms