CCL3 Rabbit Polyclonal Antibody (R1510-10)

UNIPROT #

P10855

PROTEIN NAME

CCL3

SYNONYMS

C C motif chemokine 3 antibody;CCL 3 antibody;CCL3 antibody;CCL3_HUMAN antibody;Chemokine C C motif ligand 3 antibody;G0/G1 switch regulatory protein 19 1 antibody;G0/G1 switch regulatory protein 19-1 antibody;G0S19 1 antibody;G0S19 1 protein antibody;Heparin binding chemotaxis protein antibody;L2G25B antibody;LD78 alpha antibody;LD78-alpha(4-69) antibody;LD78alpha antibody;Macrophage inflammatory protein 1 alpha antibody;Macrophage inflammatory protein 1-alpha antibody;MIP 1 alpha antibody;MIP 1A antibody;MIP-1-alpha antibody;MIP-1-alpha(4-69) antibody;MIP1A antibody;PAT 464.1 antibody;SCYA 3 antibody;SCYA3 antibody;SIS alpha antibody;SIS beta antibody;SIS-beta antibody;Small inducible cytokine A3 antibody;small inducible cytokine A3 (homologous to mouse Mip-1a) antibody;Small-inducible cytokine A3 antibody;Tonsillar lymphocyte LD78 alpha protein antibody

SEQUENCE SIMILARITIES

Belongs to the intercrine beta (chemokine CC) family.

TISSUE SPECIFICITY

Expressed in lung, spleen, and pancreas.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1α, MIP-1β, MIP-2, MIP-3α, MIP-3β, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1β is more selective than MIP-1α, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1α is a more potent lymphocyte chemoattractant than MIP-1β and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1α has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1β and RANTES.