CCR3 Rabbit Polyclonal Antibody
Catalog# ER1905-72
CCR3 Rabbit Polyclonal Antibody
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IHC-P
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IF-Tissue
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Human
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Rat
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unconjugated
Overview
Product Name
CCR3 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CCR3: 251-355/355
Species Reactivity
Human, Rat
Validated Applications
IHC-P, IF-Tissue
Molecular Weight
41 kDa
Positive Control
In eosinophils as well as trace amounts in neutrophils and monocytes.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
IHC-P
-
1:100-500
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IF-tissue
-
1:100-500
Target
Function
C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene. The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils,[6] and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.
Background References
暂无
Subcellular Location
Cell membrane; Multi-pass membrane protein.
UNIPROT
Synonyms
B chemokine receptor antibody
b-chemokine receptor antibody
C C chemokine receptor type 3 antibody
C C CKR 3 antibody
C-C chemokine receptor type 3 antibody
C-C CKR-3 antibody
CC chemokine receptor 3 antibody
CC chemokine receptor type 3 antibody
CC CKR 3 antibody
CC R3 antibody
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Products with the same target and pathway
CCR3 Rabbit Polyclonal Antibody
Application: WB,IF-Cell
Reactivity: Human
Conjugate: unconjugated
