CHRNA7 Mouse Monoclonal Antibody [G1-F10]

Function

Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChRα7, also known as NACHRA7, CHRNA7-2 or CHRNA7, is a 502 amino acid multi-pass membrane protein existing as a homopentamer and interacts with RIC-3, a nicotinic acetylcholine receptor (nAChR)-associated protein.

Background References

1. Revathikumar P et al. Immunomodulatory effects of nicotine on interleukin 1 activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism. J Neuroinflammation 13:256 (2016).

2. el-Mas MM et al. Estrogen dependence of the renal vasodilatory effect of nicotine in rats: role of a7 nicotinic cholinergic receptor/eNOS signaling. Life Sci 88:187-93 (2011).

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane. Cell membrane

UNIPROT

SwissProt: P36544 Human

Synonyms